A Mammalian H + Channel Generated Through Alternative Splicing of the NADPH Oxidase Homolog NOH-1
- 7 January 2000
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 287 (5450) , 138-142
- https://doi.org/10.1126/science.287.5450.138
Abstract
Voltage-gated proton (H + ) channels are found in many human and animal tissues and play an important role in cellular defense against acidic stress. However, a molecular identification of these unique ion conductances has so far not been achieved. A 191–amino acid protein is described that, upon heterologous expression, has properties indistinguishable from those of native H + channels. This protein is generated through alternative splicing of messenger RNA derived from the gene NOH-1 (NADPH oxidase homolog 1, where NADPH is the reduced form of nicotinamide adenine dinucleotide phosphate).Keywords
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