ENHANCED NON-ELECTROLYTE UPTAKE INVITRO BY DOG JEJUNAL MUCOSA IN CHOLERA-TOXIN-INDUCED SECRETORY PHASE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 73  (1) , 5-12
Abstract
A characteristic secretory response in the dog jejunum is observed following 3 h perfusion with cholera toxin. When this mucosa in the secretory phase is examined in vitro, the steady-state accumulation of phenylalanine and .beta.-methyl-glucoside is considerably enhanced. Since the initial rates of influx of these substrates are unchanged and the tissue ion contents are the same as normal, the increase in steady-state uptake may be attributed to a change in the rate of efflux of the substrates across the baso-lateral membrane of the cell. This change might be related to the reported collapse of the intercellular channels when the intestine is in a secretory state.