Some Neurological Complications of Serum Therapy
- 22 June 1940
- Vol. 1 (4146) , 1015-1016
- https://doi.org/10.1136/bmj.1.4146.1015
Abstract
Of 120 authentic cases reported in the literature more than half have followed tetanus antitoxin injn., although every type of serum commonly employed and even human blood transfusion have been incriminated. About 20% of the cases are left with varying degrees of disability. The explanation most generally accepted is that a perineural edema, similar to the edema of serum disease, causes a compression and local blood deficiency (ischemia) resulting in paralysis of nerve trunks. Other theories suggest a direct toxin action on the nervous system or a perivascular infiltration with widespread hemorrhage in the brain and spinal cord, such as has been found in exptl. anaphylaxis.This publication has 0 references indexed in Scilit: