THE LIVER IN ULCERATIVE DISEASE OF THE INTESTINAL TRACT: FUNCTIONAL AND ANATOMIC CHANGES

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Abstract
The existence of the specific pathologic entity of "amebic hepatitis" was brought under question by many recent studies. Nevertheless, liver enlargement was observed in cases of fatal amebiasis without abscess formation. A comparable enlargement was found in the present study of regional enteritis and ulcerative colitis. Because similar liver changes were found in 3 different ulcerative intestinal diseases, it was postulated that a common secondary effect was present. The absorption of toxins and necrotic debris and malabsorption of vitamins was felt to explain these changes. It was therefore suggested that a good dietary and vitamin regimen be instituted even without evidence of hepatic dysfunction as a good prophylaxis against liver damage.