Stereocontrolled synthesis of andrimid and a structural requirement for the activity

1 January 1989

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications

No. 5,p. 299-301
https://doi.org/10.1039/c39890000299

Abstract

Total synthesis of an antibiotic Andrimid was accomplished stereospecifically; it was shown that the chiralities at C-3 and C-4 should be R and S, respectively, and the presence of the (4S)-methyl group is important for the activity.

Keywords

STRUCTURAL REQUIREMENT
STEREOCONTROLLED SYNTHESIS
TOTAL SYNTHESIS
ACCOMPLISHED STEREOSPECIFICALLY
ACTIVITY TOTAL
METHYL GROUP
ANTIBIOTIC ANDRIMID