l-Prolinamide-catalyzed direct nitroso aldol reactions of α-branched aldehydes: a distinct regioselectivity from that withl-proline
- 7 December 2005
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 4,p. 429-431
- https://doi.org/10.1039/b514194j
Abstract
The first direct enantioselective N-nitroso aldol reaction of aldehyde with nitrosobenzene catalyzed by an L-prolinamide derivative is presented; the reactions proceed smoothly furnishing the α-hydroxyamino carbonyl compounds, the otherwise disfavored products, in good yields with up to 64% ee.Keywords
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