DITHIOCARBAMIC ACID DERIVATIVES I

Abstract
The relation of chemical structure to activity was such that with each type of derivative studied the lower members (methyl and ethyl compounds) are the most active and the higher alkyl derivatives relatively inactive. Tetramethylthiuram di-sulfide was the most active compound studied. Although tetramethylthiuram monosulfide was relatively low in an antibacterial activity its high activity against fungi compares favorably with tetramethylthiuram disulfide the most active fungistatic compound studied. Further generalizations regarding the relationship of chemical structure to activity are discussed.
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