Renal Oxalate Excretion in Calcium Urolithiasis

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Abstract
Urinary oxalate was determined in an ambulatory setting in 107 patients with an increased intestinal Ca absorption rate: 34 patients with normal Ca absorption in whom stones formed and 34 control subjects without stones. Urinary oxalate excretion was not significantly different when the diet was changed from a random to a Ca-restricted diet. Moreover, urinary oxalate was not higher during summer months when intestinal Ca absorption may have been stimulated. Diet history disclosed that many patients with an increased Ca absorption rate had been on a moderate oxalate-restricted diet, often as part of a Ca-restricted regimen for the control of hypercalciuria. Renal oxalate excretion in an ambulatory setting is not critically dependent on the state of Ca absorption and intake, and the imposition of a low Ca dietary regimen in patients in whom stones form with an increased Ca absorption does not necessarily augment oxalate excretion.