Effect of cortisone and desoxycorticosterone on distribution of radioactive potassium in the adrenalectomized rat

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Abstract
Earlier work has shown that adrenalectomized animals can be kept in good condition with normal plasma K by an adrenal fraction which does not maintain a plasma Na concentration above that characteristic of adrenal insufficiency. Cortisone, which is one of the least effective Na retainers, has been used to study its influence on the uptake of injected K42 in the adrenalectomized rat. In doses of 5 mg/day cortisone corrected the deficient uptake of K42 by tissues of adrenalectomized rats so that they behaved normally except that the uptake was slow. Whether or not physiological amounts of cortisone would do this was not determined. DCA had little influence on K42 movement under our conditions.

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