ADVANCES IN ANTIBIOTIC THERAPY

Publisher Website
Google Scholar
Abstract
Erythromycin is well-tolerated and clinically effective as an orally admd. alternate for penicillin. To date, lack of clinical experience prevents critical evaluation of carbomycin. Benzethacil and penethamate hydriodide, 2 re-cently introduced forms of penicillin, have definite limitations . to their clinical applications, while polymxin B is well-tolerated and of great value against Pseudomonas aeruginosa under care-fully controlled conditions. Methods of management of infections with penicillin-resistant staphylococci are outlined and chlor-amphenicol and erythromycin are cited as particularly useful in this situation. Current discrepancies between practical applica-tion of combination antibiotic therapy and theoretic concepts concerning antibiotic synergism and antagonism are discussed. Antibiotic toxicity presents a small but definite problem, for, while the case against chloramphenicol is weak, serious unto-ward reactions have been observed with every antibiotic in general use today.