Synthesis of ent-Haterumalide NA (ent-Oocydin A) Methyl Ester
- 11 October 2003
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (23) , 4385-4388
- https://doi.org/10.1021/ol0356789
Abstract
[reaction: see text] Stille coupling of allylic chloride 26 with vinylstannane 4a afforded 65% of 27 with the requisite skipped diene, vinyl chloride, and allylic oxygen functionality. Yamaguchi macrolactonization of 28 provided 65% of 29, which was elaborated to haterumalide NA methyl ester (32) by a Nozaki-Hiyama-Kishi coupling with 31.Keywords
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