Submucosal collagen changes in the normal colon and in diverticular disease
- 1 December 1987
- journal article
- Published by Springer Nature in International Journal of Colorectal Disease
- Vol. 2 (4) , 208-213
- https://doi.org/10.1007/bf01649507
Abstract
Full thickness specimens of normal colon (n=15), and colon from patients with diverticular disease (n = 5) were obtained at operation or autopsy. In the isolated submucosa the ultrastructure of the constituent collagen fibres was examined by transmission electron microscopy. Collagen fibrils in the left colon become smaller (p < 0.001) and more tightly packed (p< 0.001) than those in the right colon with increasing age. This difference is accentuated in diverticular disease (p<0.01). Factors which contribute to the development of colonic diverticulosis, such as raised intraluminal pressure, may be responsible for premature change in submucosal structure.Keywords
This publication has 9 references indexed in Scilit:
- The submucosa of the human colonJournal of Ultrastructure and Molecular Structure Research, 1986
- Pathology of the ageing--diverticular disease.1985
- Mechanical properties of the colon: comparison of the features of the African and European colon in vitro.Gut, 1985
- Collagen Fibril Diameters and Glycosaminoglycan Content of Skins— Indices of Tissue Maturity and FunctionConnective Tissue Research, 1984
- Ultrastructural Properties of Collagen Fibrils in Rat IntestineConnective Tissue Research, 1983
- A comparison of the size distribution of collagen fibrils in connective tissues as a function of age and a possible relation between fibril size distribution and mechanical propertiesProceedings of the Royal Society of London. B. Biological Sciences, 1978
- MORPHOLOGIC STUDY OF SUBMUCOSA OF LARGE-INTESTINE1977
- Intraluminal Pressure in the Sigmoid ColonScandinavian Journal of Gastroenterology, 1976
- Intraluminal pressure in the sigmoid colon. II. Patients with sigmoid diverticula and related conditions.1976