The Mainz Classification of Renal Cell Tumors

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Abstract
Background: Tumors arising from the renal tubular epithelium have variable characteristics and have been subject to a variety of histologic classifications. Methods: The authors describe the distinct clinical, pathologic, phenotypic, and genotypic features of different types of renal tumors. Results: The Mainz classification is now widely accepted because characteristic genetic alterations have been demonstrated in each tumor type. Conclusions: The increasing emphasis on utilizing genetic characteristics of specific tumors is reflected by the more widespread use of the Mainz classification for renal cell tumors.