Further studies on the suppressing effect of isoproterenol on the immobility-reducing action of desipramine in the forced swimming test.

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Abstract
Whether the suppressing effect of intracerebroventricular (i.c.v.) administration of isoproterenol (ISO) on the immobility-reducing action of desipramine (DMI) [a tricyclic antidepressant] in the forced swimming test was mediated through the presynaptic noradrenaline [norepinephrine] (NA) neurons and presynaptic .alpha.2-adrenoceptors in rat brain was studied. As in the case of DMI, phenylephrine (i.c.v.) and yohimbine (i.p.) reduced the duration of immobility. The actions of DMI and yohimbine but not that of phenylephrine were diminished and potentiated by i.c.v. administration of ISO and atenolol, respectively. The suppressing effects of ISO were almost completely blocked by the pretreatment with atenolol. Clonidine (s.s.) diminished the action of DMI as did ISO, although clonidine had no effect on the duration of immobility when given alone. The suppressing effect of clonidine was antagonized by the pretreatment with yohimbine at a dose which did not affect the duration of immobility, when given alone, nor influenced the action of DMI; the effect of ISO was not affected by the same dose of yohimbine. The suppressing effect of ISO on the immobility-reducing action of DMI in the forced swimming test is apparently mediated through the presynaptic NA neurons, and ISO acts through the presynaptic .beta.1- but not .alpha.2-adrenoceptors.

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