123I-Interleukin-2 uptake in squamous cell carcinoma of the head and neck carcinoma
- 10 October 2007
- journal article
- research article
- Published by Springer Nature in European Journal of Nuclear Medicine and Molecular Imaging
- Vol. 35 (2) , 281-286
- https://doi.org/10.1007/s00259-007-0609-9
Abstract
Information obtained on the IL-2 receptor status of tumour infiltrating lymphocytes in patients suffering from squamous cell carcinoma of the head and neck (SSCHN) before and after IL-2 treatment may lead to a better understanding of the immunological changes and related kinetics induced at the tumour level and ultimately to a strategy that allows selection of those patients that will benefit from IL-2 therapy. This study set out to assess the relationship between 123I-IL2 single-photon emission computed tomography (SPECT) findings and the presence of IL-2 receptors (CD25 staining) on tumour-infiltrating lymphocytes as well as on SCCHN tumour cells in patients suffering from SCCHN.Keywords
This publication has 28 references indexed in Scilit:
- Interleukin-2 for the treatment of solid tumors other than melanoma and renal cell carcinomaAnti-Cancer Drugs, 2006
- Targeting the immune system: novel therapeutic approaches in squamous cell carcinoma of the head and neckCancer Immunology, Immunotherapy, 2004
- 123I-Interleukin-2: biochemical characterization and in vivo use for imaging autoimmune diseasesNuclear Medicine Communications, 2003
- Improved survival with perilymphatic interleukin 2 in patients with resectable squamous cell carcinoma of the oral cavity and oropharynxCancer, 2002
- Interleukin-2 expression in human carcinoma cell lines and its role in cell cycle progressionOncogene, 2000
- Expression of interleukin 2 receptors on human carcinoma cell lines and tumor growth inhibition by interleukin 2International Journal of Cancer, 1994
- Interleukin-2 in cancer treatment: Disappointing or (still) promising? A reviewCancer Immunology, Immunotherapy, 1993
- Interleukin‐2 injected around tumor‐draining lymph nodes in head and neck cancerHead & Neck, 1991
- Evaluation of Therapeutic Potential of Interleukin 2- Expanded Tumor-Infiltrating Lymphocytes in Squamous Cell Carcinoma of the Head and NeckAnnals of Otology, Rhinology & Laryngology, 1988
- An immunohistologic study of the distribution and status of activation of head and neck tumor infiltrating leukocytesEuropean Archives of Oto-Rhino-Laryngology, 1987