Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family.
- 1 November 1987
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 84 (21) , 7649-7653
- https://doi.org/10.1073/pnas.84.21.7649
Abstract
Antigen receptors on the surface of the thymus-derived (T) lymphocytes are associated with small integral membrane proteins called the T3 (CD3) .gamma., .delta., .epsilon., and .zeta. chains. After interaction of the T-cell receptor with antigen, the T3 proteins are believed to transfer an activation signal to the intracellular compartment. In previous studies, the human .gamma., .epsilon., and .delta., chains have been cloned along with the mouse .delta. chain but a relationship between these sequences and known molecular families has not been established. We now report the molecular cloning and characterization of the murine T3-.epsilon. protein and a sequence and structural analysis of the relationships between all the T3 chains and the immunoglobulin superfamily. It is established that the T3 chains are immunoglobulin-related and a particular relationship to the neural cell adhesion molecule (N-CAM) is noted. This sequence relationship adds interest to previous findings that the T3 chains are genetically linked to N-CAM and Thy-1 antigen on band q23 of human chromosome 11.This publication has 23 references indexed in Scilit:
- The T-cell receptor gamma chain-CD3 complex: implication in the cytotoxic activity of a CD3+ CD4- CD8- human natural killer clone.Proceedings of the National Academy of Sciences, 1987
- The gene encoding the epsilon subunit of the T3/T-cell receptor complex maps to chromosome 11 in humans and to chromosome 9 in mice.Proceedings of the National Academy of Sciences, 1987
- Striking similarities between antigen receptor J pieces and sequence in the second chain of the murine CD8 antigenNature, 1986
- A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytesNature, 1986
- Identification of a putative second T-cell receptorNature, 1986
- Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complexNature, 1986
- Sequence of a cDNA clone encoding the polysialic acid-rich and cytoplasmic domains of the neural cell adhesion molecule N-CAM.Proceedings of the National Academy of Sciences, 1986
- Secondary, tertiary, and quaternary structure of T-cell-specific immunoglobulin-like polypeptide chains.Proceedings of the National Academy of Sciences, 1986
- Identification of the components of the murine T cell antigen receptor complexCell, 1985
- DNA sequencing with chain-terminating inhibitorsProceedings of the National Academy of Sciences, 1977