METABOLISM OF ARILDONE, AN ANTI-VIRAL AGENT, IN LABORATORY-ANIMALS
- 1 January 1981
- journal article
- research article
- Vol. 9 (5) , 424-427
Abstract
After arildone administration, 4 compounds were identified in the excreta of laboratory animals: unchanged drug, arildone; the O-desmethyl metabolite, 4-[6-(2-chloro-4-hydroxy)phenoxy]hexyl-3,5-heptanedione; the sulfate ester of 2-chloro-4-methoxyphenol; and a labile conjugate of chlorohydroquinone tentatively characterized as the sulfate ester. The concentrations of each of these were determined in the urine and/or plasma of rats, dogs and mice after administration of 14C-arildone.This publication has 3 references indexed in Scilit:
- Inhibition of uncoating of poliovirus by arildone, a new antiviral drugVirology, 1979
- Preliminary Studies of the Mode of Action of Arildone, a Novel Antiviral AgentAntimicrobial Agents and Chemotherapy, 1979
- Antiviral activity of some .beta.-diketones. 2. Aryloxy alkyl diketones. In vitro activity against both RNA and DNA virusesJournal of Medicinal Chemistry, 1977