Substitution of Ser for Arg-443 in the Regulatory Domain of Human Housekeeping (GLUD1) Glutamate Dehydrogenase Virtually Abolishes Basal Activity and Markedly Alters the Activation of the Enzyme by ADP and l-Leucine
Open Access
- 1 November 2002
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 277 (48) , 46552-46558
- https://doi.org/10.1074/jbc.m208596200
Abstract
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This publication has 30 references indexed in Scilit:
- Differential expression of glutamate dehydrogenase in cultured neurons and astrocytes from mouse cerebellum and cerebral cortexJournal of Neuroscience Research, 2001
- Hyperinsulinism and Hyperammonemia in Infants with Regulatory Mutations of the Glutamate Dehydrogenase GeneNew England Journal of Medicine, 1998
- Nerve Tissue‐Specific Human Glutamate Dehydrogenase that Is Thermolabile and Highly Regulated by ADPJournal of Neurochemistry, 1997
- Quantitative ultrastructural localization of glutamate dehydrogenase in the rat cerebellar cortexNeuroscience, 1994
- Regulation of the glutamate dehydrogenase activity in rat islets of Langerhans and its consequence on insulin releaseMetabolism, 1994
- l-glutamate dehydrogenases: Distribution, properties and mechanismComparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1993
- Glial glutamate dehydrogenase: Ultrastructural localization and regional distribution in relation to the mitochondrial enzyme, cytochrome oxidaseJournal of Neuroscience Research, 1987
- L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenaseNature, 1980
- Comparison of the effects of leucines, non-metabolizable leucine analogues and other insulin secretagogues on the activity of glutamate dehydrogenaseActa Diabetologica, 1976
- 5 Glutamate DehydrogenasesPublished by Elsevier ,1975