The effect of bleomycin and radiation in combination on bacteria and mammalian cells in culture

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Abstract
Studies have been carried out into the effect of bleomycin and radiation in combination on the survival of three bacterial strains and two mammalian cell lines. When the bleomycin was present before and/or during irradiation, the effect of the two agents was merely additive for all the cell types studied. It was found, however, that when E. coli B/r were exposed to bleomycin after irradiation, the decrease in survival was considerably greater than would have been produced merely by addition of the effects of the two agents. Such a decrease was not, however, observed for E. coli Bs-1, Micrococcos radiodurans, EMT6 mouse tumour cells or HeLa cells. The results are discussed with reference to possible clinical significance.