THE CONCENTRATION AND SYNTHESIS OF GLYCOSAMINOGLYCANS IN THE SKIN AND TRACHEAL CARTILAGE OF NORMAL AND ORCHIDECTOMIZED RATS INJECTED WITH TESTOSTERONE

1 February 1970

journal article
Published by Oxford University Press (OUP) in Acta Endocrinologica

Vol. 63 (2) , 193-198
https://doi.org/10.1530/acta.0.0630193

Abstract

Normal and orchidectomized rats were injected on alternate days with 10 mg of testosterone for 20 days in order to study the effect of the hormone on both the distribution and the rate of synthesis of glycosaminoglycans in the skin and tracheal cartilage. Testosterone exerts a very specific effect on the acidic glycosaminoglycans by increasing the hyaluronic acid concentration more than twice. The sulphated fractions do not appear to be affected. The above increase in probably due to an augmentation of synthesis of hyaluronate, as evidenced by an increased uptake of ¹⁴C acetate by this fraction.

Keywords

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