Caspase-9 Inhibition after Focal Cerebral Ischemia Improves Outcome following Reversible Focal Ischemia
- 1 January 2002
- journal article
- Published by Springer Nature in Metabolic Brain Disease
- Vol. 17 (3) , 143-151
- https://doi.org/10.1023/a:1019921904378
Abstract
Cerebral ischemia initiates a program of cell death known as apoptosis. Early steps in these death promoting events are the release of cytochrome cfrom the mitochondria and activation of caspase-9....Keywords
This publication has 38 references indexed in Scilit:
- Caspase Inhibitors Reduce Neuronal Injury After Focal but Not Global Cerebral Ischemia in RatsStroke, 2000
- All along the watchtower: on the regulation of apoptosis regulatorsThe FASEB Journal, 1999
- Diva, a Bcl-2 Homologue that Binds Directly to Apaf-1 and Induces BH3-independent Cell DeathJournal of Biological Chemistry, 1998
- WD-40 Repeat Region Regulates Apaf-1 Self-association and Procaspase-9 ActivationPublished by Elsevier ,1998
- Prolonged Therapeutic Window for Ischemic Brain Damage Caused by Delayed Caspase ActivationJournal of Cerebral Blood Flow & Metabolism, 1998
- Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury.Journal of Clinical Investigation, 1998
- Intact, injured, necrotic and apoptotic cells after focal cerebral ischemia in the ratJournal of the Neurological Sciences, 1998
- Conversion of Bcl-2 to a Bax-like Death Effector by CaspasesScience, 1997
- Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damageProceedings of the National Academy of Sciences, 1997
- Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria BlockedScience, 1997