The herpes simplex virus ICP27 protein: a multifunctional post-transcriptional regulator of gene expression
- 1 June 2005
- journal article
- Published by Portland Press Ltd. in Biochemical Society Transactions
- Vol. 33 (3) , 499-501
- https://doi.org/10.1042/bst0330499
Abstract
The herpes simplex virus 1 ICP27 is an essential, highly conserved protein involved in various steps of herpes simplex virus 1 gene regulation as well as in the shut-off of host gene expression during infection. It functions primarily at the post-transcriptional level in inhibiting precursor mRNA splicing and in promoting nuclear export of viral transcripts. These activities are discussed.Keywords
This publication has 53 references indexed in Scilit:
- The Evolutionarily Conserved Kaposi's Sarcoma-associated Herpesvirus ORF57 Protein Interacts with REF Protein and Acts as an RNA Export FactorJournal of Biological Chemistry, 2004
- Viral Regulation of mRNA ExportJournal of Virology, 2004
- ICP27 Selectively Regulates the Cytoplasmic Localization of a Subset of Viral Transcripts in Herpes Simplex Virus Type 1-Infected CellsJournal of Virology, 2004
- The spliceosome: the most complex macromolecular machine in the cell?BioEssays, 2003
- Identification of Herpes Simplex Virus RNAs That Interact Specifically with Regulatory Protein ICP27 in VivoJournal of Biological Chemistry, 2003
- Mapping of Functional Regions in the Amino-Terminal Portion of the Herpes Simplex Virus ICP27 Regulatory Protein: Importance of the Leucine-Rich Nuclear Export Signal and RGG Box RNA-Binding DomainJournal of Virology, 2002
- Nuclear Localization and Shuttling of Herpes Simplex Virus Tegument Protein VP13/14Journal of Virology, 2001
- Interaction between Herpes Simplex Virus Type 1 IE63 Protein and Cellular Protein p32Journal of Virology, 2000
- A herpesvirus regulatory protein appears to act post-transcriptionally by affecting mRNA processing.Genes & Development, 1992
- Redistribution of nuclear ribonucleoprotein antigens during herpes simplex virus infection.The Journal of cell biology, 1987