A Microcomputer-Based Differential Lung Ventilation System

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Abstract
In order to provide a versatile means of delivering differential lung ventilation (DLV), a computer-controlled system was constructed to allow a variety of ventilation protocols as well as to record and monitor relevant physiologic parameters. Two Siemens servo ventilators were modified for synchronous operation and computer control of minute volume and respiratory rate. Twenty-five parameters on the two lungs were collected every breath. Feedback control was used to adjust respiratory rate to maintain PaCO2 = 35 torr and to keep total tidal volume equal to 15 mI/kg. Three differential volume delivery protocols were established. The DLV system was evaluated in a study involving eighteen mongrel dogs (six dogs for each volume delivery protocol), each with a unilateral lung injury caused by an infusion of 0.1 N HOC through the endobronchial tube. This system has proven to be a highly effective and versatile means of providing differential ventilation as well as precise feedback control of essential physiologic parameters such as PaCO2 and tidal volume. The system handles automated data collection of all relevant physiological parameters, making graphical as well as statistical analysis extremely easy.