A Molecular Defect in Lathyritic Collagen.

Publisher Website
Google Scholar
Abstract
Electrophoretic and peptide fingerprint studies carried out on formic acid extracted collagen from the skins of control and lathyritic rats provided evidence that the excess soluble collagen molecules which accumulate in the tissues of lathyritic animals are intrinsically normal. But the lathyritic molecules are dramatically deficient in aldegens exert their effect on connective tissues by causing an inhibition of the oxidative deamination which appears to precede con-valent crosslink formation in collagen and elastin.