Effect of Pentagastrin on Gastric Mucosal Nucleic Acid Synthesis of Fed Guinea Pigs
- 1 January 1980
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 20 (2) , 106-110
- https://doi.org/10.1159/000137351
Abstract
In normally fed guinea pigs the effect of a sustained release pentagastrin preparation was studied on gastric mucosal weight, protein, DNA and RNA concentration and thymidine and uridine incorporation into DNA and RNA, respectively. Treatment with pentagastrin for 3 days significantly increased antral and fundic mucosal DNA and RNA concentration and thymidine and uridine incorporation. It is concluded that pentagastrin stimulates gastric mucosal nucleic acid synthesis beyond the driving force elicited by food.Keywords
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