Studies on lactams. Part 45. Some carbocyclic analogues of cephalosporin
- 1 January 1976
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 20,p. 2193-2197
- https://doi.org/10.1039/p19760002193
Abstract
Several polycyclic β-lactams have been synthesized by the reactions of cyclic imines with acid chlorides in the presence of triethylamine. The azido-functions in these β-lactams were reduced to amino-groups, which were then acylated with phenylacetyl chloride to introduce the penicillin G side chain. Some carbocyclic analogues of cephalosporin were found to possess antibacterial activity.This publication has 2 references indexed in Scilit:
- A convenient nomenclature for fused β‐lactamsJournal of Heterocyclic Chemistry, 1976
- An Improves Method for the Cleavage of Methyl EstersSynthetic Communications, 1972