Learning impairment in mice following acute exposure to dichloromethane and carbon tetrachloride

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Abstract
Mice were exposed via inhalation to high concentrations of dichloromethane (168 mg/l) or CCl4 (134.3 mg/l). The mice were tested for learning ability using a passive-avoidance conditioniong task. Exposed animals had a significantly decreased ability to learn when compared with controls. The 3-wk-old mice were more affected than the 5- and the 8-wk-old mice. The exposed animals were indistinguishable from controls in terms of motor activity, weight gain and absence of analgesia.