Isotretinoin for Acne

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Abstract
The report in 1979 by Peck et al. that treatment of severe, therapy-resistant acne with oral isotretinoin (13-cis-retinoic acid) effected complete remission of the disease evoked much excitement and eager expectation.1 A particularly striking observation was that patients given this synthetic vitamin A derivative remained free of disease for prolonged periods after the completion of a course of treatment lasting four to five months. This was in contradistinction to the effect of traditional acne therapies that ordinarily require long-term use for suppression.Since September 1982, when oral isotretinoin was first marketed for use in the United States, more . . .

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