The Andro Project

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Abstract
A SIGNIFICANT decline in functional capacity with increasing age strongly correlates with a loss in muscle mass. Starting at age 30 years, a person will loose 10% of skeletal muscle content by age 60 years.1,2 Thereafter, muscle mass loss accelerates in most senior adults.1,2 In conjunction with changes in muscle mass, declines in several tissue-promoting hormones including insulinlike growth factor, growth hormone, testosterone, and calcitriophic factors occur.3 Whether the declines in these hormone levels directly cause skeletal muscle mass (SMM) losses or are simply a concomitant consequence of aging is unclear.