Microinjection of ras p21 induces a rapid rise in intracellular pH.
Open Access
- 1 May 1987
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 7 (5) , 1984-1988
- https://doi.org/10.1128/mcb.7.5.1984
Abstract
Quiescent mouse NIH 3T3 cells responded to microinjection of activated ras p21 with a rapid and sustained rise in intracellular pH (approximately 0.17 pH units). The p21-induced pH change was inhibited by amiloride treatment or growth of cells in medium low in sodium, suggesting a role for the Na+/H+ antiporter. Amiloride was found to suppress p21-induced mitosis, also.This publication has 39 references indexed in Scilit:
- Growth factor-like action of phosphatidic acidNature, 1986
- Ras p21 proteins with high or low GTPase activity can efficiently transform NIH3T3 cellsCell, 1986
- Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogeneNature, 1983
- Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologueNature, 1983
- A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogeneNature, 1982
- The transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus contain tightly bound lipidPublished by Elsevier ,1982
- Phorbol ester stimulation of Na influx and Na-K pump activity in swiss 3T3 cellsBiochemical and Biophysical Research Communications, 1981
- MONOVALENT ION FLUXES AND THE CONTROL OF CELL PROLIFERATION IN CULTURED FIBROBLASTSAnnals of the New York Academy of Sciences, 1980
- Increased sodium ion influx is necessary to initiate rat hepatocyte proliferationCell, 1979
- Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situBiochemistry, 1979