Atrioventricular Conduction in Dogs during Anesthesia with Isoflurane

Abstract
The effects of 1.25, 2.0, and 2.5 MAC [minimum anesthetic concentration] isoflurane on atrioventricular conduction were studied by His-bundle electrocardiography during atrial pacing in 10 dogs. No effect upon atrioventricular conduction as evidenced by changes in A-H interval (the time of conduction from low right atrium to His-bundle, representing primary AV nodal conduction) was found at these concentrations. Atrial pacing to 200 beats/min did not influence the A-H interval at the 3 anesthetic concentrations. The stability of cardiac rhythm observed clinically with isoflurane may be related to this lack of effect upon the AV node.

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