EFFECT OF AN OESTROGEN ANTAGONIST ETHAMOXY-TRIPHETOL (MER-25) ON OESTROUS BEHAVIOUR IN RATS

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Abstract
MER-25, 75–150 mg/kg, inhibited oestrous behaviour induced by oestradiol benzoate/progesterone treatment in ovariectomized rats. In experiments in which MER-25 was administered 2 hours before oestradiol benzoate, the extent of antagonism was dependent on the dose of MER-25. Single injections of MER-25, given at different time intervals in conjunction with oestrogen administration, showed that MER-25 effectively decreased the response when administered either 2 hours before, or 2 or 8 hours after oestradiol benzoate treatment. No significant effect occurred when MER-25 was given simultaneously with, 12 hours before, or 24 hours after the oestrogen injection. MER-25 had no effect when oestradiol was given instead of oestradiol benzoate in otherwise analogous experiments. It seems probable that the inability of MER-25 to antagonize the effect of oestradiol in these experiments was due to the fact that MER-25 cannot compete with the comparatively high dose of oestradiol which was necessary to obtain the same response as in the oestradiol benzoate experiments.

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