Effect of X-Irradiation on Intestinal Motility of the Rat

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Abstract
One min. following exposure to 100 r consistently increased intestinal tone and motility. Degree and length of tone rise increased with the dose. During the first hr. following 800 r, propulsive motility was accelerated but decreased to or below normal from the 3d hr. through the 3d day, then returned to normal. Apparently X-irradiation stimulated the cholinergic nerves. Atropine, epinephrine, nicotine, curare, tetraethylammonium chloride inhibited the X-irradiation; physostigmine caused augmentation. The X-irradiation acted directly on the intestine with little systemic component. The vagus action was chiefly at the level of the enteric ganglia.

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