Protection by 4-amino-hex-5-enoic acid (?-vinyl GABA) and hypobaric hypoxia against kainic acid neurotoxicity
- 1 November 1979
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 66 (1) , 51-53
- https://doi.org/10.1007/bf00431989
Abstract
The behavioral effects following IP injection of kainic acid in rats could be cancelled with hypobaric hypoxia (8% O2 corresponding to 7000 m altitude) or with IP injections of 7-amino-hex-5-enoic acid at a dose of 0.9 g/kg-1. This protection may result from increased accumulations of GABA in brain tissues.Keywords
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