Soft-Tissue Infections of Ampicillin-Resistant Haemophilus influenzae Type b

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Abstract
• The combination of intravenous ampicillin sodium and nafcillin sodium followed by oral ampicillin and dicloxacillin sodium was effective in treating five infants with soft-tissue infections and bacteremia due to β-lactamase—producing, ampicillin-resistant Haemophilus influenzae type b. This antibiotic combination seems to be an effective alternative to chloramphenicol for treatment of nonmeningitic invasive disease due to moderately ampicillin-resistant (minimum inhibitory concentration, 2 to 25 μg/mL) H influenzae type b. The use of this combination should be in conjunction with appropriate in vitro tests whose results demonstrate synergism. (Am J Dis Child 1981;135:410-412)