An Argument for Vitamin E Supplementation in the Management of Systemic Inflammatory Response Syndrome
- 1 February 2003
- journal article
- review article
- Published by Wolters Kluwer Health in Shock
- Vol. 19 (2) , 99-103
- https://doi.org/10.1097/00024382-200302000-00001
Abstract
The systemic inflammatory response syndrome results from an uncontrolled, overexpression of the normal host inflammatory response, leading to destruction of host tissue and subsequent organ failure. Oxidant stress has been implicated in this process both as a mechanism for direct cellular injury, as well as activation of intracellular signaling cascades within inflammatory cells resulting in progression of the inflammatory response. Vitamin E is an inexpensive, nontoxic, chain-breaking antioxidant that has therapeutic potential in regulating this process. This review seeks to evaluate the current literature regarding the use of Vitamin E in controlling the excessive inflammation seen in systemic inflammatory response syndrome and argues for further study of its therapeutic potential for these critically ill patients.Keywords
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