Tyrosine Kinase May Participate in Ca2+ Entry for Endothelial Nitric Oxide Production
Open Access
- 1 January 1995
- journal article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 67 (2) , 181-184
- https://doi.org/10.1254/jjp.67.181
Abstract
We have suggested that cyclopiazonic acid (CPA), a Ca(2+)-ATPase inhibitor, produces nitric oxide (NO) by triggering a Ca(2+)-influx resulting from Ca(2+)-depletion in the endoplasmic reticulum of endothelial cells. The tyrosine kinase inhibitor methyl 2,5-dihydroxycinnamate, while having no effect on relaxations induced by A23187 or Na nitroprusside, did inhibit the CPA-induced relaxation and cyclic GMP formation in rat aorta. Tyrosine kinase may participate in endothelial NO synthesis through activation of a Ca2+ entry mechanism.Keywords
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