Single-Dose Antibiotic Treatment of Asymptomatic Gonorrhea in Hospitalized Women

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Abstract
Single-dose treatment of asymptomatic gonorrhea was studied in 396 Filipino women hospitalized to prevent reinfections. Endocervical cultures were obtained for six days after treatment to detect failures. Failure rates of 13 to 44 per cent were seen with varying doses of a parenteral penicillin G preparation given without probenecid. No failures occurred in 80 patients given 6,000,000 units of parenteral penicillin G with probenecid, or in 108 patients given 3.5 g of ampicillin orally with or without probenecid.