Analgesic Nitrous Oxide for Alcohol Withdrawal is Better than Placebo
- 1 January 1989
- journal article
- clinical trial
- Published by Taylor & Francis in International Journal of Neuroscience
- Vol. 49 (1-2) , 71-74
- https://doi.org/10.3109/00207458909087040
Abstract
We present data distinguishing the placebo response from the action of analgesic nitrous oxide in alcohol withdrawal. We also discuss the difficulties of undertaking double-blind controlled studies when using analgesic nitrous oxide as an active agent. A novel method of overcoming these problems is presented. The role of the postulated hyperalgesic opioid system in the negative placebo response is mentioned.Keywords
This publication has 8 references indexed in Scilit:
- THE EFFECT OF PLACEBO IN THE ALCOHOL WITHDRAWAL STATEAlcohol and Alcoholism, 1989
- Analgesic (sub anesthetic) nitrous oxide interacts with the endogenous opiod system: A review of the evidenceLife Sciences, 1986
- Nitrous oxide, an opioid addictive agentThe American Journal of Medicine, 1986
- Psychological preparation influences nitrous oxide analgesia: Replication of laboratory findings in a clinical settingOral Surgery, Oral Medicine, Oral Pathology, 1986
- A pharmacological overview of opioid mechanisms mediating analgesia and hyperalgesiaNeurological Research, 1985
- Paradoxical effect of naloxone on nitrous oxide analgesia in manEuropean Journal of Pharmacology, 1980
- THE MECHANISM OF PLACEBO ANALGESIAThe Lancet, 1978
- States of Heightened Suggestibility: NarcosisJournal of Mental Science, 1945