In vitro metabolism of a new 4-hydroxycoumarin anticoagulant. Structure of an unusual metabolite

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Abstract
The metabolism of clocoumarol, 3-[1-[p-(2-chloroethyl)phenyl]butyl]-4-hydroxycoumarin, by rat liver microsomes was investigated. The chemical structure of the main metabolite is 6-[1-hydroxy-2-oxo-3-[p-(2-chloroethyl)-phenyl]hexylidene]-2,4-cyclohexadien-1-one; such a structure has not been previously reported for metabolites from anticoagulants of the 4-hydroxycoumarin group.