Skin Reactivity in Guinea Pigs Sensitized to Flea Bites: The Sequence of Reactions

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Abstract
Experimental evidence is presented which, for the first time, demonstrates the occurrence of a definite sequence of events in the skin reactions of guinea pigs following repeated exposure to flea bites. The sequence was: I-induction of sensitivity; II-predominately delayed skin reactivity; Ill-delayed and immediate responses; IV-predominately immediate reactivity; V-non-reactivity.

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