The Mechanism of Histamine Binding to Heparin
- 1 January 1979
- journal article
- letter
- Published by Taylor & Francis in International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
- Vol. 35 (2) , 177-182
- https://doi.org/10.1080/09553007914550191
Abstract
The interaction between polyanions and cations is electrostatic in nature, since it is characterized by its dependence on pH and ionic strenth. Many of the properties of heparin, including its anticoagulant activity and histamine binding capacity, are due to its ability to bind to organic and inorganic ions or molecules. The ability is related to the type, number and distribution of ionizable groups on the heparin molecule, coupled with a size effect. Pulse radiolysis and the spectroscopic method were used to evaluate the limiting concentration for the destruction of a heparin-MB+ [methylene blue] complex by histamine and N-acetyl histamine over the pH range 3-11 to investigate the mechanism of histamine binding to heparin.This publication has 13 references indexed in Scilit:
- Polyanions and their complexes. Part IX. Binding affinities of inorganic ions to heparinJournal of the Chemical Society, Perkin Transactions 2, 1974
- Polyanions and their complexes. Part VII. Mechanism of methylene blue–polyanion interactionsJ. Chem. Soc. A, 1970
- Binding of Cationic Dyes to Nucleic Acids and Other Biological PolyanionsNature, 1966
- Differential staining of acid glycosaminoglycans (mucopolysaccharides) by Alcian blue in salt solutionsHistochemistry and Cell Biology, 1965
- Pulse radiolysis apparatusJournal of Scientific Instruments, 1964
- Bedeutung von Zink für die Histaminspeicherung in MastzellenInternational Archives of Allergy and Immunology, 1963
- Measurement of the Stability of Metachromatic CompoundsJournal of the American Chemical Society, 1962
- Histamine binding by heparinArchives of Biochemistry and Biophysics, 1962
- SECTION OF CHEMICAL SCIENCES: MOLECULAR BIOPHYSICS OF DYE‐POLYMER COMPLEXESTransactions of the New York Academy of Sciences, 1961
- The Reversible Polymerization and Molecular Aggregation.The Journal of Physical Chemistry, 1950