DNA replication and models for the origin of piRNAs
- 20 March 2007
- Vol. 29 (4) , 382-385
- https://doi.org/10.1002/bies.20557
Abstract
The piRNA class of small RNAs are distinct from other small RNAs by their ∼26–31 nucleotide size, single-strandedness and strand-specificity as well as by the clustered arrangement of their origins. Here, we highlight how these features are reminiscent of the mechanisms of DNA replication, and then present three models suggesting that the origin of piRNAs may be mechanistically similar to key processes in DNA replication. BioEssays 29:382–385, 2007.Keywords
This publication has 23 references indexed in Scilit:
- A dynamic model for replication protein A (RPA) function in DNA processing pathwaysNucleic Acids Research, 2006
- A novel class of small RNAs in mouse spermatogenic cellsGenes & Development, 2006
- Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testesGenes & Development, 2006
- A germline-specific class of small RNAs binds mammalian Piwi proteinsNature, 2006
- A Toxic Mutator and Selection Alternative to the Non-Mendelian RNA Cache Hypothesis for hothead ReversionPlant Cell, 2005
- The promiscuous primaseTrends in Genetics, 2005
- RNA cache or genome trash?Nature, 2005
- Hothead healer and extragenomic informationNature, 2005
- Gene therapy progress and prospects: targeted gene repairGene Therapy, 2005
- Genetic Engineering Using Homologous RecombinationAnnual Review of Genetics, 2002