EVALUATION OF LYMPHOCYTE-T SUBPOPULATIONS IN CHILDREN WITH NEPHROTIC SYNDROME
- 1 January 1983
- journal article
- research article
- Vol. 52 (3) , 581-585
Abstract
Lymphocyte subsets were evaluated both quantitatively and functionally in children with nephrotic syndrome. Ten chidren had minimal change nephrotic syndrome (MCNS), 7 had focal segmental glomerular sclerosis (FSGS) and 4 had recovered from MCNS. Two patients with FSGS had decreased OKT4+ cells and a decreased T4/T8 ratio. Patients with active MCNS synthesized significantly less IgM in vitro than did normal subjects (P < 0.005). In vitro IgG synthesis was significantly decreased in patients with active nephrotic syndrome whether it was due to MCNS or FSGS. Co-culture studies involving lymphocyte subsets suggested that both patients with decreased percentages of T4+ cells had decreased T helper cell activity as well. The results support previous speculation about abnormal immune function in some patients with nephrotic syndrome.This publication has 14 references indexed in Scilit:
- T-Cell Dysfunction in Minimal-Change Nephrotic Syndrome of ChildhoodArchives of Pediatrics & Adolescent Medicine, 1982
- LONG-TERM IMPAIRMENT OF SUPPRESSOR-CELL FUNCTION BY CYCLOPHOSPHAMIDE IN MINIMAL-CHANGE NEPHROPATHY AND ITS ASSOCIATION WITH THERAPEUTIC RESPONSEThe Lancet, 1981
- Monoclonal Antibodies Defining Distinctive Human T Cell Surface AntigensScience, 1979
- A serum inhibitor of blastogenesis in idiopathic nephrotic syndrome transferred by lymphocytesClinical Immunology and Immunopathology, 1979
- INHIBITION OF LYMPHOCYTE BLASTOGENESIS BY PLASMA OF PATIENTS WITH MINIMAL-CHANGE NEPHROTIC SYNDROMEThe Lancet, 1976
- EVIDENCE FOR CELL-MEDIATED IMMUNITY TO RENAL ANTIGENS IN MINIMAL-CHANGE NEPHROTIC SYNDROMEThe Lancet, 1976
- Serum Immunoglobulins in Idiopathic Minimal-Change Nephrotic SyndromeNew England Journal of Medicine, 1976
- PATHOGENESIS OF LIPOID NEPHROSIS: A DISORDER OF T-CELL FUNCTIONThe Lancet, 1974
- Immunochemical Semiquantitative Estimation of γM-and γA-immunoglobulins in Healthy and Diseased Children. Part 2. Immunoglobulin Levels in Nephrotic Syndrome, Exudative Enteropathy, Acute Leukemia, and Malignant Tumors.Pediatrics International, 1965
- STUDIES ON THE METABOLISM OF PLASMA PROTEINS IN THE NEPHROTIC SYNDROME. I. ALBUMIN, γ-GLOBULIN AND IRON-BINDING GLOBULIN 1Journal of Clinical Investigation, 1956