Effet d'une souche de Lactobacillus sur la cinétique d'établissement de Shigella flexneri et d'Escherichia coli dans le tube digestif de souriceaux "Gnotoxéniques." Rôle de l'immunisation des mères

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Abstract
A strain of either Shigella flexneri, Escherichia coli, or each of these two strains with a strain of Lactobacillus is implanted in the digestive tract of different couples of axenic adult mice.Some pregnant mothers are vaccinated with the three strains before implantation. The vaccination does not change the kinetics establishment of all three bacterial strains in either the mothers or the young.Escherichia coli is established at its maximum level in "monoxenic" young mice at day 3 after birth, while Shigella appears slowly and irregularly during the 1st week of life. Both strains are established almost simultaneously in the stomach and intestine of the young mice.Lactobacillus is established at maximum level in the stomach and intestine of "dixenic" young mice at day 1 after birth. In these conditions, Shigella appears slowly, only reaching maximum level at 17 days. This antagonistic effect is especially observed in the stomach of the animals, and in a small measure, in the intestine. The establishment of E. coli is hardly affected by the presence of Lactobacillus, except in the stomach in most young animals.In no case is there interference between Lactobacillus and either one of the two strains after 3 weeks of age.

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