Biosynthesis of C4 (Fourth Component of Complement) by Hybrids of C4-Deficient Guinea Pig Cells and HeLa Cells
- 2 June 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 176 (4038) , 1029-1031
- https://doi.org/10.1126/science.176.4038.1029
Abstract
Peritoneal exudate cells from guinea pigs homozygous for a genetic deficiency of the fourth component of complement (C4) were fused in vitro with a cell line of human origin (HeLa). The resulting hybrid cells, derived from cell lines each incapable of C4 synthesis by themselves, synthesized functionally active human C4.Keywords
This publication has 11 references indexed in Scilit:
- Immune Hemolysis and the Functional Properties of the Second (C2) and Fourth (C4) Components of ComplementThe Journal of Immunology, 1971
- Genetically Controlled Total Deficiency of the Fourth Component of Complement in the Guinea PigScience, 1970
- Inherited deficiency of the third component of human complement (C′3)Journal of Clinical Investigation, 1969
- DEFICIENCY OF THE SIXTH COMPONENT OF COMPLEMENT IN RABBITS WITH AN INHERITED COMPLEMENT DEFECTThe Journal of Experimental Medicine, 1966
- Hereditary deficiency of the second component of complement (C'2) in man.Journal of Clinical Investigation, 1966
- Autosomal Polymorphism via a Translocation in the Guinea Pig, Cavia porcellus L.Cytogenetic and Genome Research, 1966
- A Method for the Culture of Leucocytes of the Guinea Pig (Cavia cobaya) with Karyotype AnalysisCytogenetic and Genome Research, 1966
- A biochemical abnormality in hereditary angioneurotic edemaThe American Journal of Medicine, 1963
- A METHOD OF SELECTING FOR AUXOTROPHIC MUTANTS OF HELA CELLSThe Journal of Experimental Medicine, 1960
- An Air-Drying Technique for Flattening Chromosomes in Mammalian Cells GrownIn VitroStain Technology, 1958