Review of Methods in “Breast Augmentation: A Risk Factor for Breast Cancer?”

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Abstract
We are writing to follow up on the article by Berkel et al. concerning breast implants and the risk of cancer (June 18, 1992, issue).1 The study was a population-based, noncurrent cohort-linkage study, which was performed under the auspices of the Alberta Cancer Board. Essentially, the study was designed to identify women who had undergone cosmetic breast augmentation between 1973 and 1986 and to link this cohort of women with the Alberta Cancer Registry to determine which women with implants subsequently had breast cancer. The actual breast-cancer rates were compared with the expected rates, which were calculated by applying age-specific incidence rates for breast cancer to the entire cohort's person-years at risk. The standardized incidence ratio reported was 47.6 percent, which was interpreted to mean that the rate of breast cancer in the implant group was significantly lower than expected.

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