THE PYRUVIC PHOSPHOFERASE OF ERYTHROCYTES: II. ACTIVITY IN ANEMIC AND TUMOR-BEARING ANIMALS AND IN HUMAN BLOOD DISORDERS

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Abstract
Pyruvic phosphoferase (PPFase) activity of the erythro- cytes (RBC) was determined in rabbits and rats made anemic by acetylphenylhydrazine injection or by bleeding, in rats bearing the Walker 256 carcinoma, and in human patients suffering from anemia, including several cases of pernicious anemia. An elevation of the PPFase activity was found to accompany the appearance of new RBC in the circulation, but the enzyme level was not always related to the proportion of reticulocytes or the mean RBC volume. Administration of vitamin B12 to a previously untreated case of pernicious anemia resulted in a marked increase in the PPFase activity during regeneration of RBC. The highest PPFase activity was found in a patient with nutritional microcytic anemia.