Gastric Mucosal Damage Induced by Non-Steroid Anti-Inflammatory Agents in Rats of Different Ages

1 January 1972

journal article
Published by S. Karger AG in Pharmacology

Vol. 8 (4) , 321-328
https://doi.org/10.1159/000136348

Abstract

Experiments in rats of different ages have shown that juvenile animals are less sensitive than adults to the gastric irritant effects of non-steroid anti-inflammatory drugs, such as acetylsalicylic acid, oxyphenbutazone and phenylbutazone, although the anti-oedematous activity ofthese drugs is equally potent in all agegroups.

Keywords

ACETYLSALICYLIC ACID
AGE DEPENDENCY OF ACTIONS
ANTI-OEDEMATOUS ACTIVITY
CINCHOPHEN
FLUFENAMIC ACID
INDOMETHACIN
OXYPHENBUTAZONE
PHENYLBUTAZONE
ULCEROGENIC EFFECT

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