The Therapeutic Potential of Fetal and Neonatal Hematopoietic Stem Cells

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Abstract
The transplantation of allogeneic hematopoietic stem cells is being used to treat thousands of adults and children with life-threatening hematologic diseases. In the absence of a suitable HLA-identical sibling donor, possible alternatives are mismatched related or matched unrelated donors. But with cells from these donors, major and minor histocompatibility differences, which often go unrecognized by current matching tests, are a frequent cause of post-transplantation complications, graft failure, graft-versus-host disease, and delayed immune reconstitution. In the absence of a perfectly matched donor, several means of circumventing the HLA barrier are possible. Some of these depend on the special hematologic and immunologic . . .